How cholera toxin is modified and crosses the ER membrane to trigger intoxication
How polyomavirus penetrates the ER membrane to cause infection
Our laboratory is fundamentally interested in understanding how toxins and viruses hijack host cell machineries to cause disease. Specifically, we are probing the molecular mechanism by which cholera toxin penetrates the endoplasmic reticulum (ER) membrane to reach the cytosol, a decisive intoxication pathway. Similarly, our laboratory also investigates how a DNA tumor virus, polyomavirus, breaches the ER membrane, a crucial infection step. In these efforts, we have unveiled many cellular components co-opted by the toxin and virus during their membrane penetration. These insights should provide therapeutic targets to combat diseases caused by these toxic agents and illuminate novel membrane transport mechanisms.