* equal contributors


53.  Inoue T, Zhang P, Zhang W, Goodner-Bingham K, Dupzyk A, DiMaio D, Tsai B Gamma-secretase promotes membrane insertion of the human papillomavirus L2                 capsid protein during virus infection. J. Cell Biology. (in press)

52.  Dupzyk A, Tsai B Bag2 is a component of a cytosolic extraction machinery that promotes membrane penetration of a nonenveloped virus. J. Virol.

51.  Ravindran MS, Spriggs CC, Verhey KJ, Tsai B Dynein engages and dissasembles cytosol-localized SV40 to promote infection. J. Virol.

50.  Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P Misfolded proinsulin in the endoplasmic reticulum during development of beta cell           failure in diabetes Annals of the New York Academy of Sciences.



49.  Inoue T, Tsai B. Regulated Erlin-dependent release of the B12 J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathog.

48.  Ravindran MS*, Engelke MF, Verhey KJ, Tsai B*. Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration siteNat Commun.

47.  Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B. SGTA-dependent regulation of Hsc70 promotes cytosol entry of SV40 from the ER.  J Virol.

46.  Qi L, Tsai B, Arvan P. New Insights into the Physiological Role of ER-associated degradation. Trends Cell Biol.

45.  Cunningham CN*, He K*, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B. Chaperone-driven degradation of a misfolded proinsulin mutant in parallel with                         restoration of wild-type insulin secretion. Diabetes.



44.  Bagchi P, Inoue T, Tsai B. EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus. eLife.

43.  Dupzyk A, Tsai B. How polyomaviruses exploit the ERAD machinery to cause infection. Viruses.

42.  Ravindran MS*, Bagchi P*, Cunningham C, Tsai B. Opportunistic intruders: Viruses orchestrate the ER function to cause infection. Nat Rev Micro.

41.  Williams JM, Tsai B. Intracellular trafficking of bacterial toxins. Curr Opin Cell Biology.

40.  Ravindran MS, Tsai B. Viruses utilize cellular cues in distinct combination to undergo systematic priming and uncoating. PLoS Pathog.

39.  Inoue T, Tsai B. The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients. Mol Biol Cell.

38.  Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P. Disulfide mispairing during proinsulin folding in the Endoplasmic Reticulum. Diabetes.

37.  Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber R, Shen X, Lee A, Iwawaki T, Paton A, Paton J, Fang D, Tsai B, Yates J, Wu H,            Kersten S, Long Q, Duhamel G, Simpson KW, Qi L. IRE1α is an endogenous substrate of Endoplasmic Reticulum-associated degradation. Nat Cell Biol.



36.  He K*, Ravindran MS*, Tsai B. A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathway to cause disease. Crit Rev                       Biochem Mol Biol.

35.  He K*, Cunningham C*, Manickam N, Liu M, Arvan P*, Tsai B*. PDI reductase acts on Akita mutant proinsulin to initiate retro-translocation along the Hrd1/Sel1L-p97         axis. Mol Biol Cell.

34.  Ravindran MS, Bagchi P, Inoue T, Tsai B. A non-enveloped virus hijacks host disaggregation machinery to translocate across the Endoplasmic reticulum                             membrane. PLoS Pathog.

33.  Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B. ERdj5 reductase cooperates with protein disulfide isomerase to promote SV40                                     Endoplasmic reticulum membrane translocation. J Virol.

32.  Williams JM, Inoue T, Chen G, Tsai B. The NEF Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation. Mol Biol Cell.

31.  Inoue T, Tsai B. A nucleotide exchange factor promotes ER-to-cytosol membrane penetration of the nonenveloped virus Simian virus 40. J Virol.

30.  Bagchi P, Walczak CP, Tsai B. The ER membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration. J Virol.



29.  Walczak CP, Ravindran MS, Inoue T, Tsai B. A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the               Endoplasmic reticulum. PLoS Pathog.

28.  Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B. A deubiquitinase negatively regulates retro-translocation of non-ubiquitinated substratesMolBiolCell.

27.  Moore P, He K, Tsai B. Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell                     receptor-α retro-translocationPLoS One.

26.  Williams JM, Inoue T, Banks L, Tsai B. The ERdj5-Sel1L complex facilitates cholera toxin retro-translocationMol Biol Cell.

25.  Inoue T, Tsai B. How viruses use the endoplasmic reticulum for entry, replication, and assembly. Cold Spring Harb Perspect Biol.

24.  Walczak CP, Bernardi KM, Tsai B. ER-dependent redox reactions control ER-associated degradation and pathogen entryAntioxid Redox Signal.



23.  Inoue T, Tsai B. A large and intact viral particle penetrates the ER membrane to reach the cytosolPLoS Pathog.

22.  Walczak CP, Tsai B. A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection. J Virol

21.  Bradbury FA, Tsai B. Functional versus decoy receptor-regulated entry of polyomaviruses. Future Virology.

20.  Inoue T, Moore P, Tsai B. How viruses and toxins disassemble to enter host cells. Annu Rev Microbiol. (*equal contributors)

19.  Goodwin E, Lipovsky A, Inoue T, Magaldi T, Edwards APB, Yates KE, Paton AW, Paton JC, Atwood W, Tsai B, DiMaio D. BiP and multiple DnaJ molecular                           chaperones in the endoplasmic reticulum are required for efficient SV40 infectionmBio.

18.  Bernardi, KM, Williams JM, Kikkert M, van Voorden S, Wiertz EJ, Ye Y, Tsai B. The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin                             retro-translocationMol Biol Cell.

17.  Moore P, Bernardi KM, Tsai B. The Ero1alpha-PDI redox cycle regulates retro-translocation of cholera toxin. Mol Biol Cell.

16.  Tsai B, Qian M. Cellular entry of polyomaviruses. Curr Top Microbiol Immunol.

15.  Qian M, Tsai B. Lipids and proteins acts in opposing manners to regulate polyomavirus infection. J Virol.

14.  Tsai B, Inoue T. A virus takes an “L” turn to find its receptor. Cell Host Microbe.



13.  Rainey-Barger EK, Mkrchian S, Tsai B. The C-terminal domain of ERp29 mediates polyomavirus binding, unfolding, and infectionJ Virol.

12.  Jiang M, Abend JR, Tsai B, Imperiale, MJ. Early events during BK virus entry and disassemblyJ Virol.

11.  Forster ML, Mahn J, Tsai B. Generating an unfoldase from thioredoxin-like domainsJ Biol Chem.

10.  Qian M, Cai D, Verhey KJ, Tsai B. A lipid receptor sorts polyomavirus from the endolysosome to the endoplasmic reticulum to cause infection. PLoS Pathog.

09.  Erickson KD, Garcea RL, Tsai B. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirusJ Virol.

08.  Lam AD, Tryoen-Toth P, Tsai B, Vitale V, Stuenkel EL. SNARE-catalyzed fusion events are regulated by syntaxin1A-lipid interactionsMol Biol Cell.

07.  Bernardi KM, Forster ML, Lencer WI, Tsai B. Derlin-1 facilitates the retro-translocation of cholera toxinMol Biol Cell.

06.  Rainey-Barger EK, Mkrtchian S, Tsai B. Dimerization of ERp29, a PDI-like protein, is essential for its diverse functionsMol Biol Cell.

05.  Tsai B (2007). Penetration of non-enveloped viruses into the cytoplasmAnnu Rev Cell Dev Biol.

04.  Rainey-Barger EK, Magnuson B, Tsai B. A chaperone-activated non-enveloped virus perforates the physiologically relevant ER membraneJ Virol.

03.  Low JA, Magnuson B, Tsai B, Imperiale MJ (2006). Identification of gangliosides GD1b and GT1b as receptors for BK virusJ Virol.

02.  Forster LM, Sivick K, Park Y-N, Arvan P, Lencer W, Tsai B (2006). Protein disulfide isomerase-like proteins play opposing roles during retro-translocationJCB.

01.  Magnuson B, Rainey EK, Benjamin T, Baryshev M, Mkrtchian S, Tsai B. ERp29 triggers a conformational change in polyomavirus to stimulate membrane                             bindingMol Cell.




Tsai  Lab