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In these times when people are overfed but undernourished, supplements can compliment an intensive workout regimen. In fact the best muscle-gain supplements aid natural process already occurring in the body with an energy boost (Creatine), speed muscle-recuperation after a workout or prevent fatigue. Nitric oxide may also increase blood-flow to organs and tissues. Muscle gain supplements, therefore, are supplements, not substitutions, for diet combined with a rigorous bodybuilding program.